Downstream process development
Purify your products with our downstream process development CDMO solutions designed to achieve higher yields and greater cost-effectiveness.
What is downstream process development?
Downstream processing is an essential step in biologics production. The products of upstream processing are purified and isolated from the cell culture harvest, which contains a mixture of proteins, impurities and cellular debris. Our downstream process development capabilities are designed to achieve high yields with low costs and are compatible with both fed-batch and continuous processing.
What modalities can we handle with our downstream process development?
- Monoclonal antibodies (mAbs)
- Therapeutic recombinant proteins
- Recombinant enzymes
- Conjugated proteins
- Bispecific proteins
- Fusion proteins
- Synthetic peptides
- Plasmid DNA (pDNA)
- Phytopharmaceuticals
Understanding our downstream process development approach
Our downstream process development CDMO solutions include:
Early-stage/pre-clinical
- Purify your biologics with capture, intermediate and polishing steps
- Ion exchange, metal-chelate, hydrophobic interaction, ceramic hydroxyapatite, gel permeation, reverse-phase, mixed-mode, pseudo-affinity and filtration-based chromatography capabilities
Late-stage/clinical/commercial
- Refine and lockdown your process for scale-up
- Identify any process changes, establish process robustness and consistency and prepare for scale-up
Why partner with Enzene for downstream process development?
We are a global CDMO and biosimilar developer dedicated to impacting the global healthcare landscape by bringing trusted and affordable medicines to market, quickly.
Committed to innovation, we have revolutionized biologics production with our patented and validated continuous bioprocess manufacturing platform, EnzeneX™, that enables us to significantly reduce the cost of producing complex biologics and monoclonal antibodies (mAbs).
Our fully-integrated services and productive pipeline of biosimilars, along with our downstream process development solutions, are designed to cater to your project’s every need.
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Join the CDMO revolution
Fueled by our continuous innovation and armed with EnzeneX™, our fully-integrated CDMO solutions and our biosimilars pipeline are designed to help bring your biologics innovations to life.