Harness the power of our advanced antibody discovery platforms to accelerate your therapeutic development. From cancer to autoimmune disorders, we're here to transform your targets into ground-breaking treatments.
Antibody discovery is a sophisticated process that employs advanced methodologies to identify and develop antibodies with specific binding affinities to target antigens. Successful campaigns lead to therapeutics for various diseases, including cancer, autoimmune disorders and infections, advancing personalized medicine and treatment efficacy. This process is equally effective in generating highly specific reagent antibodies for research purposes.
Enzene employs a diverse strategy for antibody discovery, combining:
Libraries generated through these processes undergo rigorous selection to isolate sequences with the highest specificity and affinity for the target. AI/ML tools integrated at various screening stages accelerate lead candidate identification, enhancing efficiency and speed. After identification, antibodies are characterized through affinity maturation and epitope mapping to optimize binding and functionality. Advanced methods like X-ray crystallography or cryo-EM are used to elucidate antibody-antigen interactions at the atomic level.
Display engineering fine-tunes discovered antibody candidates to match desirable properties or “design goals,” improving drug characteristics such as target binding affinity, functionality and cross-species reactivity. Two key techniques in this field are phage display and yeast display, both of which excel in antibody engineering and sequence optimization:
Phage display:
Yeast display
This critical stage involves systematic evaluation of promising candidates using:
Screening assays are utilized at multiple steps throughout the antibody discovery workflow to ensure the selection of the most promising candidates.
This step ensures that candidates possess desirable drug-like properties before advancing to preclinical and clinical development. The evaluation focuses on:
Enzene offers a seamless transition from discovery to development:
This integrated approach allows clients to achieve top speed to the clinic with their lead candidates.
Fueled by our continuous innovation and armed with EnzeneX™, our fully-integrated CDMO solutions and our biosimilars pipeline are designed to help bring your biologics innovations to life.