Bispecific proteins

Why develop bispecific proteins?

Bispecific proteins have two distinct binding domains, enabling them to simultaneously engage two different cell surface receptors or antigens. This means they can mediate interactions between different cell types or modulate multiple signaling pathways.

Bispecific proteins are promising therapeutic agents because they can:

• Elicit multivalent binding: The simultaneous binding of two different antigens, which can lead to enhanced specificity and increased target cell engagement, improves the efficacy of immune cell activation and target cell killing
• Enhance specificity: The higher specificity reduces the risk of off-target effects and minimizes the potential for adverse events
• Enable immune modulation: The modulation of immune responses by engaging different immune cell types and activating or inhibiting specific signaling pathways can enhance the anti-tumor immune response and promote immune cell cytotoxicity
• Overcome resistance: Bispecific proteins can overcome resistance mechanisms and maintain therapeutic efficacy, providing an advantage compared to conventional therapies

We can help with bispecific protein development, overcoming the challenges of complex manufacturing processes, potential immunogenicity, and the need for careful design to ensure optimal binding properties and functionality.

Understanding our bispecific protein production

Our development and manufacturing capabilities, experience and expert scientific team have all the tools to produce efficacious bispecific proteins safely. We can cater and optimize processes to your product, including:

• Perfusion and fed-batch process upstream development
• Downstream process development
• Process characterization
• Tech transfer and scale-up
• Integrated continuous bioprocess manufacturing via our platform EnzeneX™, including process analytical technology (PAT)