Recombinant enzymes

Why develop recombinant enzymes?

Recombinant enzymes hold great promise for treating a wide range of diseases, but their development and manufacturing present several challenges, including:

• Host selection: Choosing and optimizing the host organism for recombinant enzyme production is crucial
• Expression and purification: Optimizing enzyme expression and purification is essential for obtaining high yields of pure, active enzymes. This often involves screening different expression systems, purification methods and refolding strategies
• Stability and storage: Recombinant enzymes can be susceptible to degradation and inactivation by various factors such as temperature, pH and proteases. Maintaining enzyme stability during production, storage and delivery is a significant challenge
• Scalability and cost-effectiveness: Manufacturing recombinant enzymes at a commercial scale requires scalable and cost-effective processes. This includes optimizing fermentation conditions, developing efficient purification methods and implementing quality control measures
• Regulatory considerations: Recombinant enzyme drug therapies are subject to stringent regulatory requirements. Compliance with these regulations is essential for ensuring the safety and efficacy of the product

By bringing our expertise and experience to your project, we can help you navigate these challenges with confidence and bring your recombinant enzyme therapies to life.

Understanding our recombinant enzyme production

Our expert scientific team is well-positioned to overcome challenges with effective strategies in place to navigate development and manufacturing. Starting from cell line development, through to manufacturing, scale-up and fill and finish, we can leverage our diverse expertise, state-of-the-art facilities and validated fed-batch and continuous manufacturing approaches for high-yielding, safe and efficacious therapeutic enzymes.